Forgot to add I really suffer from a Yo Yo effect where symptoms deteriorate and then improve again taking about 3/4 and sometimes 5 days after starting dosing to recover, as it were.

Maybe a sign that I should increase dosing amounts in the first couple of days and decrease them after say 2/3 days.
I'm on 1.0mg/kg but maybe I should start of on 1.2mg or 1.5mg and then go back to 1.0mg as a sort of maintenace dosing?

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Into the heart, an air that kills, from yon far country blows.
What are those blue remembered hills, what sphires what farms are those.
That is the land of lost content,I see it shining plain,
The happy highways where I went and cannot come again

May fatigue be an effect of a slight methemogobinemia?

If so, the increased level of methemoglobin may perhaps be picked up by a sufficiently sensitive oxymeter and the trend therefore may be possible to discern in relation to a sufficient number of comparative readings during OFF-phases.

Are you able to link the relevtive sense of fatigue to more or less sinnicant changes in recovery?

If I allow myself to wander off topic, it is strange that fatigue also is the perhaps most well known side effect of hyperoxia in HBO-treatment.

In this context it may also be interesting to note that increased fatigue also appears to be a known side effect of higher doses of NADH-supplementation, see e.g. this link.

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Don't just ask what scientists can do to speed up the solution for ALS or when they will do it, instead ask yourself what you can do right now to solve ALS asap.

Why does niacin help with the fatigue?

Louis

You might find this interesting. IN Mary Reid's recent thread DR6, p2, there is this statement: "Furthermore administration of geranylgeranyl pyrophosphate partially restored cell viability and neurite outgrowth in TDP-43 knockdown cells. "

When yo search on that long name that I will shorten to GGPP yo see it is one of the nastiest compounds you will come across. Not saying you should go out and get this stuff that will likely kill you, but the multiple discussions of TDP-43 within a few hours of each other is interesting.

I think this fact is one of the great things about this forum. It is the only place I know where there is a free-wheeling discussion of just about everything ALS.

The dosage for WF10 is somewhat along those lines if I recall correctly what I read before. 0.5mL/Kg on the first day and 0.3mL/Kg on the second and third days of infusion.

Had some more good news today.
An email from another OSC trialist - reporting leg movement gain.

He also reported it was a gain in the first place affected by ALS.

Bad news one other trialist on PLM has seen no results and has just given up taking OSC.

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Into the heart, an air that kills, from yon far country blows.
What are those blue remembered hills, what sphires what farms are those.
That is the land of lost content,I see it shining plain,
The happy highways where I went and cannot come again

It is also possible that some ALS patients are misdiagnosed. This is likely since there is no definitive biomarker yet. Progressive muscle weakness is not necessarily ALS, is it?

On another tangent, it is possible that, in some PALS, SC is not reaching the affected tissues due to poor blood circulation. Maybe using a combination of niacin and l-Arginine 1 or 2 hours before ingestion might help. Again, adding O2 therapy to the treatment helps with tissue healing. Thinking out loud.

Louis

Nem's thoughts also apply to the actual NP001 trial The neurologist and head admin always ask me what drugs I am currently taking. I have studiously told them about each drug and supplement, to the point of emailing or asking whether it is OK within the strictures of the trial to take a particular drug etc before I start.,

For a while I was heavy into antioxidants, and they said fine. And thew I stopped them due to reports herein and elsewhere, and they also said fine.

SO shat does all this off and on of the anti oxidants do to the data? I am truly curious about this and do wonder how the supposed interim report will be affected by such intake modifications.

This clearly shows that they really have no clue as to what NP001/sodium chlorite is all about.Judging from my wife's experience with anti-oxidants I would strongly advise all PALS to stay away from any kind of anti-oxidant, whether or not one is taking OSC.

My understanding of ALS tells me that it's just the immune system mistakenly over-producing reactive oxygen species (ROS) in certain areas of the spinal cord and the brain. Taking anti-oxidants causes the immune system to increase its production of ROS in those areas, thereby aggravating the problem. Taking a strong anti-oxidant, by contrast, should trick the immune system into decreasing its production of ROS.

I believe this (creating ROS) is what sodium chlorite (a very strong oxidant) does to the immune system, nothing really special that would require years of research to figure out. I suspect that the current Neuraltus-originated theory (the one that involves the production of TauCl in combating inflammation) is erroneous at best and deceptive at worst. I suspect that other common oxidants such as hydrogen peroxide or sodium chlorate may be equally effective at accomplishing the same thing. However, there is no money in those things. So it is up to those PALS that have the means to conduct their own experiments to do so.

PALS can try, for example, to undergo hyperbaric oxygen therapy for a while to see if it helps. Or they can try to get their doctors to approve hydrogen peroxide therapy. There are ways to experiment with potential therapeutics that are not very risky because they are performed by experienced technicians. They must conduct their own experiments because most ALS researchers cannot be trusted, in my opinion. They have too much invested in this.

Louis

That's a primary problem in DIYs is the protocol adherence. Too much variation destroys the integrity of the data as evidence.

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-- Le Meilleur Vin Avec Les Meilleurs Amis --

The comment above is my personal opinion. I do not represent ALS-TDI